A MECHANISTICALLY NOVEL PEPTIDE AGONIST OF THE IL-7 RECEPTOR THAT ADDRESSES LIMITATIONS OF IL-7 CYTOKINE THERAPY.

A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapy.

Interleukin (IL)-7 is broadly active on T-cell populations, and modified versions have been clinically evaluated for a variety of therapeutic applications, including cancer, lymphopenia, and infectious diseases; and found to be relatively well-tolerated and biologically active.Here we describe novel IL-7R agonists that are unrelated in structure to

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Selective sweeps on different pigmentation genes mediate convergent evolution of island melanism in two incipient bird species

Insular organisms often evolve predictable phenotypes, like flightlessness, extreme body sizes, or increased melanin deposition.The evolutionary forces and molecular targets mediating these patterns remain mostly unknown.Here we study the Chestnut-bellied Monarch (Monarcha castaneiventris) from the Solomon Islands, a complex of closely related subs

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FAKTOR-FAKTOR YANG MENDORONG PERPINDAHAN AUDITOR (AUDITOR SWITCH) PADA PERUSAHAAN-PERUSAHAAN DI SURABAYA DAN SIDOARJO

This research intends to predict factors that drive client to switch their existing auditor based on prior research undertaken Advent calendars by Chow and Rice (1982).The main independent variable used in this research is qualified audit opinion.In addition, this study also include merger, management changes and expansion as the control variables.

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